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The neonate as stated above, phenytoin induces vitamin k metabolism, which can cause a relative vitamin k deficiency, creating the potential for hemorrhagic disease of the newborn. Several epidemiologic and intervention studies have found that vitamin k deficiency causes reductions in bone mineral density and increases the risk of fractures. The american academy of pediatrics said bleeding due to vitamin k deficiency appears to be on the rise as some families decline a standard preventive measure for newborns.
These studies suggest that vitamin k deficiency causes reductions in bmd and increases the risk of fractures, resulting from the undercarboxylation of osteocalcin. Vitamin d vitamin d deficiency or insufficiency is common among individuals with obesity, so even before these patients start the medications, supplementation may be warranted. Delayed recognition of exocrine pancreatic insufficiency can lead to serious nutritional consequences
But early diagnosis and enzyme replacement therapy can improve outcomes.
The cdc has found a cluster of newborns with late vitamin k deficiency bleeding, a preventable disease that can cause brain hemorrhage, showing the importance of vitamin k injection at birth.
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